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  • Useful Articles - Silver; Not Just a Medium of Monetary Exchange, But As an Antibiotic

    Historically, silver has long been used for the preservation of food and water. Before there were other means of preservation, silver was used for the same reasons colloidal silver is used now as a mineral supplement. Food and drink
    According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product
    vessels, as well as eating utensils have been made with silver since mankind’s earliest years. The following anecdote from the writings of the Greek philosopher, Herodotus, before the birth of Christ, references this fact. The Greek historian Herodot
    ; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

    Examples of combination products may in
    us, called the "Father of History", is one of our prime sources for information known about the fall of Babylon. Herodotus lived a century after the time of Daniel and traveled widely in the East. In his "Histories", we learn of the campaign of Persia
    lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

    's King Cyrus against Babylon. The details include the fact that no Persian king, including Cyrus, would drink the water of any stream other than the Choaspes, a river that flowed past the Persian capital of Susa. Wherever the king went, a long train
    here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe
    of four-wheeled mule wagons followed him transporting silver jars filled with the river's water. The water in silver jars would keep fresh for years during the long campaigns.

    The Greeks were not the only civilization to take advantage of silver’s he
    d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

    Combination pro
    alth-encouraging properties. The Phoenicians, Romans, Egyptians and most people around the world used silver in one form or another to preserve food and water. For example, during the “Dark Ages” in Europe, silver utensils, cups and bowls were used to
    ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc
    help protect the wealthy from the full impact of the widespread pandemics. A common expression, used to this day, "born with a silver spoon in their mouth" comes from these “Dark Ages” and refers to the advantages of silver. In these days when disea
    easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi
    ses ran rampant, the wealthy gave their children silver spoons to suck on to ward off diseases. Also, in the days of the settling of the American frontier, pioneers commonly used silver coins to slow down the spoilage of milk and water.

    Although it i
    nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically
    s not widely known, today’s mainstream medicine has utilized silver for its health benefits to an extent. For instance, a silver coated nylon material was patented as "Silvalon" and licensed by FDA as an anti-microbial bandage. Also, a silver-based s
    and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ
    alve product called "Silvadine” has been used for some time now for the treatment of burns and is in virtually every burn ward in America to protect burn victims against infection. Another example is the use of dilute silver nitrate in newborn babies
    ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi
    ' eyes to protect from infection. Even before people knew the causes of most illnesses, silver served as one of man’s most reliable aids in supporting the immune system against those illnesses. In addition, to this day, silver is also being used in
    ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

    Following aspects would a
    food cutting boards, swimming pool and drinking water filters, and water filters for NASA. There is clearly an undeniable history behind the use of silver for health reasons.

    There is one common link between all of these different uses for silver.
    dd to the challenges in developing combination products:

    Which markets to tap where the combination products can do fairly well?
    Which combination prod
    This common link to all of the previously discussed uses is based on the fact that in all of them something is needed to prevent the growth and prosperity of disease and infection causing bacteria and germs. Scientific research and evidence indicates
    cts are meaningful and rational?
    Which therapeutic categories to select?
    Which Combinations can address unmet needs of the patients?
    Do combin
    that single-celled organisms cannot survive in the presence of silver. According to researchers, silver inhibits the growth of one-celled organisms by deactivating the organism’s oxygen metabolism enzymes. As a result, the organism’s cell membranes a
    tions increase the patient compliance?
    What would be the developing cost?
    How to tackle the risks encountered during combination product developmen
    re destroyed and the replication of the organism’s DNA is stopped. All of this happens through a completely natural reaction to the silver by the organisms. There is no chemical manipulation by man.

    There is also some interesting research with silv
    t?

    As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel
    er prior to the advent of patented anti-biotics. A good example that is available on the Internet is "The Use of Colloids in Health and Disease" by Alfred B. Searle, the founder of Searle Pharmaceuticals (now known as Monsanto). Although this book is
    ping new procedures for reviewing their safety, efficacy and quality.

    Professional from academic institutions, pharmaceutical industries, health care indust
    dated in some respects, it demonstrates the research that had already been done as well as that which was ongoing in the area of “colloidal silver” before more lucrative patented drugs replaced it in the marketplace. This book cites r
    y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products
    esearch done by numerous scientists and documents their findings demonstrating the germicidal properties of silver.

    One of the most widely publicized concerns today relating to biological warfare and terrorism is the fact that microbes have mutated a
    .

    As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de
    nd become resistant so that “patented” antibiotics may often be rendered ineffective. On the other hand, research and evidence indicates that one-celled organisms do not have a natural resistance to, nor can they through mutation or natural selection,
    elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

    Companies that provide selfless information through particip
    obtain a resistance to silver's anti-microbial actions, as they are often able to do with “patented” products. Again, this is why silver has historically been one of man’s most reliable tools in supporting the immune system against various maladies.


    tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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