Useful Articles - Health and Fitness

1) What do you know about orthodontic braces?

Do you have crowded teeth, tilted teeth or you just do n

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

ot like your smile. So you might need to wear an orthodontic braces which is going to apply continuous light

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

pressure on your teeth for relatively long time & this light pressure is going to move your teeth to their

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

right position. Afterwards, the bone which is lied around your teeth is going adapt itself around the new po

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

ition of your teeth after completion of the treatment which is very important to prevent your teeth from goi

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

ng back to their old position after the end of the treatment with the orthodontic braces.

2) For how l

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

ong I need to wear the orthodontic braces?

The duration of the treatment depends on the teeth & gum state o

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

health, the width of distance which should be crossed by the teeth & on the cooperation of the patient ( he

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

should attend all his appointments on time ). So treatment time differs from individual to another but most

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

ly it is between one year to three years.

Following orthodontic braces removal the patient should wear remo

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

able appliance all the day for six months & afterwards he should wear it only during the sleeping hours fo

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

r as long as the orthodontist ask. It is very important to wear this removable appliance so your teeth do no

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

t go back to their old position.

3) How many times I should visit the orthodontist during my treatment

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

?

Usually you need to see the orthodontist once per month. During your visit your doctor is going to change

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

& adjust your wires to make sure that the orthodontic braces are applying the right amount of pressure on yo

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

ur teeth to move them to their new position.

4) Dose orthodontic braces cause any pain?

After the adj

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

ustments of the orthodontic braces by the orthodontist you might feel some pain or discomfort which is usual

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

y relieved by analgesics. Had you suffered any severe or chronic pain just consult your doctor who knows how

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

to relieve your pain the right way.

5) Does age affect the success of the orthodontic treatment?

Tee

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

th movements are not affected by age. So, it is possible for old & young people to put an orthodontic braces

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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