Useful Articles - Health and Fitness

It seems like I'm always telling people that the best way to get fit, boost your metabolism, and constantly burn fat is to make sure that you work out frequently. But much of the time, I think that

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

this is interpreted as "working out five times a week", or making sure to "get to the gym every day". While this is a great habit to have, there is a way to incorporate frequency into your program a

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

an even more practical level. For example, a great nutritional practice is to eat frequently, but that doesn't mean that you try to eat "every day". You should actually be eating up to 8-10 times p

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

r day. Guess what? Exercise is no different. This may cause some jaws to drop, but there is absolutely no reason why you should not be exercising up to 8-10 times per day!

Of course, this sounds ab

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

surd and extreme. No one in their right mind is going to come to the gym 8-10 times per day. The good news is that you don't have to. A great secret to a lean and muscular body is to "grease the gro

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

ve". This means that constantly, throughout the entire day, you have small activities that you do to shoot your heart rate up just a little bit. This doesn't mean you have to breathe hard, sweat or

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

ven spend 5 minutes in a routine outside of your normal daily workout at the gym or elsewhere. It just means that you have *something*, some set of rules that you follow, to force you to do just a l

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

ittle bit, now and then, throughout the whole day.

This is where the Three Rule concept fits in. This week, try something new. Give yourself three rules, based on three different exercises. In this

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

case, let's say the three exercises are: 1) a regular or knee pushup; 2) a body weight squat; and 3) a crunch. The next step is to generate a quantifiable goal that you will reach with each rule. Pi

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

k something that is achievable, let's say 30 pushups, 30 body weight squats, and 45 crunches. So Rule 1 is that each day, you must complete 30 pushups, Rule 2 is that each day you must complete 30 b

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

dy weight squats, and Rule 3 is that is that each day you must complete 45 crunches. Your regular workout in the gym does not count as a time to complete your three rules. You must finish them somet

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

ime outside of your normal workout.

So here's how a sample day for a working professional might look. In the morning, before your cup of coffee or breakfast, you complete 10 pushups and 10 body wei

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

ht squats. Then, in the mid-morning, next to your desk at work, you complete 15 crunches. Right before you head to lunch, you do 20 more body weight squats (by the way, this completes Rule 2, and if

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

you get funny looks, just do them in the bathroom stall). After lunch, before you head in from the parking lot, you do 10 more pushups. In the mid-afternoon, it's 15 more crunches next to the desk.

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

Finally, after you're off work, at home, next to the couch, or before bed, do 10 more pushups and 15 more crunches. When it's spelled out all at once, it looks like quite a bit of work, but that ent

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

re day probably amounts to perhaps 5 total minutes of exercise. Obviously, that isn't enough to see a huge response, but when combined with a daily routine of 30-60 minutes at the gym, it's enough t

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

make a difference, because each time you do something that gets the body and limbs moving, you're pushing your metabolism up just a little bit. That little bit can amount to double digit pounds of

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

fat in a single year! The added bonus is that after your quick 30-60 second exercise break, you'll find yourself much more focused and productive.

This is something I do personally. Here are my 3 r

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

les: Rule 1) 10 1 arm pushups or 10 1 leg squats; Rule 2) 50 regular pushups; and Rule 3) 25 body weight squats. I do them all at some point throughout the day. It's a great reason (or excuse) to ge

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

up and take an active break from sitting at the computer or reading a book, as well as great way to jump start the morning. Try it out and tell me what you think - my e-mail is elite@pacificfit.net

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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