Useful Articles - Health and Fitness

Too much fat in our diet can cause obesity, which is a risk factor of many serious diseases. However, dietary fats are a source of energy for our body and they help produce compounds that regu

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

late a variety of bodily functions such as blood pressure, heart rate and blood clotting. Although our body needs a certain amount of fat to function well, too much fat can cause healthy problems. The recomm

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

ended diet for us to adopt is a low-fat diet in which our body is being supplied the amount of fat it requires and our risk of health problems is not increased. The following are some common illnesses which a

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

e caused by having too much fat in our diet.

* Heart Disease

Obesity is associated with high blood pressure and high cholesterol which can increase the risk of heart disease. Heart failure is found to be mo

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

re common in overweight people.

* Diabetes (Type II) (Non-Insulin Dependent Diabetes)

Being overweight will increase your risk for diabetes (type II). Obesity is one of the causes of increased resistance to

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

the hormone insulin. This insulin resistance is responsible for diabetes (type II).

* Osteoarthritis and Gout

Obesity can increase the risk of developing osteoarthritis in the hips and hands. Similarly, it

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

can also increase the occurrence of gout. Both these diseases cause pain and discomfort to the joints and can inhibit movement.

* Cancer

Obesity can increase the risk of developing certain cancers such as

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

breast, endometrial, colon and kidney cancers.

* Gall Bladder Disease

Too much fat in the body may cause elevated cholesterol levels. The increased secretion of cholesterol from the liver to the gall bladde

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

may cause gall bladder disease. Cholesterol is known to be a major component of most gallstones. Thus, people with high cholesterol have an increased risk of gall bladder disease.

* Fatty Liver Disease

Fat

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

ty liver disease occurs more commonly in obese people. This is a disease whereby fat deposits damage the liver tissue. As this disease has only a few symptoms, the liver may have already been severely damage

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

by the time the disease is discovered. This disease is also found in people with diabetes and high cholesterol.

* Sleep Apnea

Obesity is known to be a common cause of sleep apnea. In this condition, breat

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

hing starts and stops during sleep. It causes a person to wake up frequently during the night. Without a good night’s rest, the person may suffer fatigue and sleepiness during the day.

* Mental Problems

Ac

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

cording to reports, extremely obese people are more prone to suffer from depression. Overweight people tend to suffer from social isolation and loneliness which can in turn lead to psychological disorders suc

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

as depression.

Fats can be saturated or unsaturated. Saturated fats are harmful as they can raise low-density lipoprotein (LDL) cholesterol levels and cause coronary artery disease. Sources of saturated fa

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

ts include butter, cheese, whole milk, ice cream, egg yolks and fatty portions of beef, pork and lamb. Some vegetable fats are also saturated and these include palm, palm kennel and coconut. Unsaturated fats

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

can be monounsaturated or polyunsaturated. Monounsaturated fats and polyunsaturated fats do not raise LDL cholesterol levels. Foods with monounsaturated fats include canola, peanut and olive oils, and avocad

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

os. Polyunsaturated fats can be found in vegetable oils such as safflower, sunflower, corn, sesame, soy cottonseed oils.

Our body needs a certain amount of fat for its functions. However, we should not cons

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

ume more than the amount our body requires. If we take too much fat in our diet, we may suffer from obesity, which is related to many serious illnesses. It is critical that we adopt a low-fat diet in order t

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

avoid obesity and thus, reduce our risk of many serious illnesses. It is beneficial for us to know the kind of fats that are harmful to our body and the foods in which they are found. Thus, we can reduce ou

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

r intake of these foods and maintain a healthy weight. For more information, please visit Homecare and elderly

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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