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Asthma medication can make a big difference for people who suffer from asthma, but there are some side effects associated with

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

them. And unfortunately, many people stop taking their medication when these side effects occur, which can lead to increased ri

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

k of an asthma attack.

The side effects vary, depending on the medication in question, and their severity also varies. It can

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

ange from mild jitteriness to more severe effects. The following are some of the most common medications as well as their assoc

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

ated side effects.

Bronchodilators

Most doctors prescribe bronchodilators as a type of "rescue" inhaler. They help to relax t

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

e muscles surrounding the airways, making it easier to breathe quickly. They don't treat the underlying asthma inflammation, ho

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

ever. The technical term for these types of treatments is "beta2 agonists."

The side effects of bronchodilators are normally m

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

nor, if any occur at all, but if they are used more often than recommended, they can cause problems. These problems can include

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

an irregular or increased heart rate.

Oral Corticosteroids

Oral steroids are generally prescribed for acute asthma, when the

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

ymptoms are particularly severe. They work by reducing the inflammation in the lungs, along the bronchioles.

Because there are

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

a number of associated side effects, this type of medication is normally used for short-term asthma management. In certain case

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

- if a patient doesn't respond to other forms of treatment - these may be prescribed for longer term treatment.

Common side e

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

fects of oral steroid medications include the following:

- insomnia
- mood swings
- thinning skin
- increased h

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

ir growth

If you experience any of the following side-effects you should contact your doctor right away:

- itching and/or hiv

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

s
- breathing problems
- headache
- eye pain
- stomach pain
- pain or swelling in the lower legs

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

sudden weight gain
- vision problems

Inhaled Steroids

The side effects of inhaled steroid medications are much less sev

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

re than those associated with oral steroid medications. Because the side effects are much less common and because of the effect

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

veness of these medications, they are often prescribed to manage asthma attacks.

One of the only common side effects of this t

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

pe of medication is oral yeast infections.

Regardless of the type of medication you are using to manage asthma, if you have an

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

unusual symptoms appear you should consult with your doctor to ensure that your treatment plan is not causing further problems

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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