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    Strange as it may sound, there are payoffs when we don't succeed.

    What? You may exclaim. Before you dismiss this statement read the following
    According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product
    explanation on what payoffs you might be gain from not succeeding.

    Ask yourself the following questions for each instance success has alluded yo
    ; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

    Examples of combination products may in
    .

    1. What do I get to avoid?

    -Responsibility, love, more expectations to produce, visibility, etc.

    2. Who do I will I punish and/or love?

    -P
    lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

    arents didn't care about my achievements--lack of achievement became a way to defy them.

    -I will not be happy to punish mom and/or dad, who want
    here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe
    me to be happy.

    -Nobody cares anyway no matter what I do.

    -I won't let my parents say, "I guess we didn't do so badly after all." i.e. parents
    d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

    Combination pro
    assuage their guilt by owning my success or live vicariously through me.

    -I will not do better than my parents because I don't want to upstage t
    ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc
    em--because I love them.

    -I will not do better than my boss because I don't want to upstage him/her.

    -I will not do better than my husband beca
    easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi
    use I am afraid I will loose his love.

    3. Righteous emotion or real feeling?

    -Guilt, anger etc. I will not express the emotion honestly and let
    nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically
    it go.

    -I will complain to everyone, but the person who is involved who can do something.

    4. What guarantee am I holding out for?

    -Promise me
    and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ
    that it will work, without my need to work or change, before I will make a commitment to succeed.

    -Promise me I will be 'front page news' if I
    ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi
    ucceed.

    5. Am I manipulating with Self-pity?

    -Am I playing victim so everyone will feel sorry for me.

    -Am I being a martyr, so I can suffer i
    ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

    Following aspects would a
    silence.

    6. Am I feeling Better-than or Less-than?

    -You don't realize how great/or less than I am.

    7. What am I afraid of loosing if I succe
    dd to the challenges in developing combination products:

    Which markets to tap where the combination products can do fairly well?
    Which combination prod
    ed?

    8. Am I avoiding to strive for my success because I fear failure.

    -I will be embarrassed if I fail, therefore, I won't strive for my deepes
    cts are meaningful and rational?
    Which therapeutic categories to select?
    Which Combinations can address unmet needs of the patients?
    Do combin
    desires.

    -I avoid my deepest fear--success--being in the limelight, having to do bigger and more noteworthy achievements.

    "Our deepest fear is
    tions increase the patient compliance?
    What would be the developing cost?
    How to tackle the risks encountered during combination product developmen
    not that we are inadequate. Our deepest fear is that we are powerful beyond measure. It is our light, not our darkness, that most frightens us.
    t?

    As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel
    e ask ourselves, "Who am I to be brilliant, gorgeous, talented, fabulous?" Actually, who are you not be be? You are a child of God. Your playing
    ping new procedures for reviewing their safety, efficacy and quality.

    Professional from academic institutions, pharmaceutical industries, health care indust
    small does not serve the world. There's nothing enlightened about shrinking so that other people won't feel insecure around you. We are all meant
    y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products
    to shine as children do. We were born to make manifest the glory of God that is within us. It's not just in some of us; it's in everyone. And as
    .

    As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de
    we let our own light shine, we unconsciously give other people permission to do the same. As we're liberated from our own fear, our presence auto
    elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

    Companies that provide selfless information through particip
    atically liberates others." Marianne Williamson (Sometimes attributed to Nelson Madela as he quoted Marianne Williamson in one of his speeches)


    tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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